Fall 2009

Readings 1

Recent Developments in Health Law:The Genetic Nondiscrimination Act, Sara Abiola, Journal of Law, Medicine and Ethics winter, 856-859(2008)

Genomics:Journey to the Center of Biology, Eric S.Lander and Robert A.Weinberg, Science 287, 1777-1782 (2000)

Handout 1,

Readings 2

Folding DNA to Create Nanoscale Shapes and Patterns, Paul Rothemund, Nature 440, 297-312 (2006)

Folding DNA into Twisted and Curved Nanoscale Shapes, H.Dietz,S.M.Douglas, W.M.Shih, Science, 325725-730(1998)

Handout 2,

Homework 1

Homework 1

Readings 3

The structure and function of the bacterial chromosome, M.Thanbivhler, P.H.Viollier, and L.Shapiro, Curr.Opin.Gene.Dev. 15, 153-162 (2005)

Handout 3,

Readings 3

Chromatin Fibers, One-at-a-time, J.Zlatanova and S.H.Leuba, J.Mol.Biol. 331, 1-19 (2003)

Homework 2

Homework 2

Readings 4

The Replication of DNA in Escherichia coli, M.Meselson and F.W.Stahl, PNAS, USA 441,671-82 (1958)

Readings 5

A synthetic oscillatory network of transcriptional regulators, M.Elowitz and S.Leibler, Nature 403,335-338 (2000)

Readings 6

Life Depends on Two Kinds of Water, P.Wiggins PLOS One e1406,1016 (2008)

Readings 7

Some Aspects of E.coli Promoter Evolution Obsrved in a Molecular Evolution Experiment, S.Liu and A.Libchaber, J.Mol.Evol. 62,536-550 (2006)

MIDTERM

Readings 8

Unconventional Lift Generating mechanisms in Free Flying Butterflies, R.B.Srygley and A.R.L.Thomas, Nature 420,660-664 (2002)

Readings 9

Life at Low Reynolds Number, E.M.Purcell, Am.J.Physics 420,3-11 (1977)

Reynold's Number Handout

Readings 10

Mechanics of Microtubule-Based Extension, D.Kuchnir-Fygenson, J.F.Marko and A.Libchaber, Phys.Rev.Lett. 79,4497-4500 (1997)

Membrane Handout

Readings 9

SeqLogos: A New Way to Present Consensus Sequences, T.D.Schneider and R.M.Stephens, Nuc.Acids.Res. 18,6097-6100(1990)

Comparative Genomics Handout

Homework 2

Readings 11

What is a Hidden Markov Model?, S.R.Eddy, Nature Biotech 22,1315-1316 (2004)

Readings 12

Hidden Markov Models, S.R.Eddy, Current BIology 6,361-365 (1996)

Readings 13

Next Generation Sequencing Techniques, W.J.Ansorge, New Biotechnology 25,195-203 (2009)

Biology Tutorial Links

General Molecular Biology Introduction

DNA Structure

Bacterial Chromosome Compaction

Nucleosomes

Simplified Gene Expression

Translation

Interactive Transcription/Translation

Prions

Meselson_Stahl Experiment